Hip-hop duo Macklemore and Lewis picked up four awards - best new artist plus best rap album, song and performance.
Justin Timberlake won three, while New Zealand teenager Lorde took two including song of the year for Royals.
Sir Paul McCartney was among the other double winners and also reunited with his Beatles bandmate Ringo Starr.
The ceremony is known for its heavyweight on-stage collaborations and this year's show was opened by Jay-Z and his wife Beyonce.
Madonna joined Macklemore and Lewis to perform their anti-homophobia anthem Same Love as more than 30 couples took part in a mass wedding.
Other highlights included Daft Punk, Nile Rodgers and Pharrell Williams being joined by Stevie Wonder to perform their smash hit Get Lucky.
As well as performing, Sir Paul McCartney picked up the trophies for best music film and best rock song for Cut Me Some Slack, a collaboration with the surviving members of Nirvana.
It beat The Rolling Stones' Doom And Gloom, from their 50th anniversary album GRRR!, as well as tracks by veteran metal band Black Sabbath, stadium rockers Muse and US singer-guitarist Gary Clark Jr.
Black Sabbath did scoop best metal performance, while Led Zeppelin won best rock album for their live recording Celebration Day.
Other British nominees included Ed Sheeran and James Blake, who were both up for best new artist, but lost out to Macklemore and Lewis.
Rapper Macklemore and producer Ryan Lewis, who found fame after self-releasing their album The Heist, were up for a total of seven awards, including album of the year and song of the year for Same Love.
"I want to say we made this album without a record label, we made it independently and we appreciate all the support," Macklemore told the audience.
Seventeen-year-old Lorde's debut hit Royals earned her song of the year and best pop solo performance after enjoying global success last year.
Jay-Z started the night with the most nominations, up for awards including best rap song and best rap album.
Rapper Kendrick Lamar, hitmaker Pharrell Williams and pop superstar Justin Timberlake were among the other acts with seven nominations.
Many of the 82 winners were named at a preliminary ceremony before the main televised event. They included Adele's James Bond theme Skyfall, which won the prize for best song written for visual media.
Calvin Harris was up for best dance/electronica album for 18 Months and best dance recording for Sweet Nothing with Florence and the Machine's Florence Welch, but lost out on both.
UK acts Duke Dumont and Disclosure were also unsuccessful nominees in the dance categories.
THE KEY WINNERS ARE:
Record of the year
Get Lucky - Daft Punk featuring Pharrell Williams & Nile Rodgers
Album of the year
Random Access Memories - Daft Punk
Song of the year
Royals - Lorde
Best new artist
Macklemore & Ryan Lewis
Best pop solo performance
Royals - Lorde
Best pop duo/group performance
Get Lucky - Daft Punk featuring Pharrell Williams & Nile Rodgers
Best pop vocal album
Unorthodox Jukebox - Bruno Mars
Best dance recording
Clarity - Zedd featuring Foxes
Best dance/electronica album
Random Access Memories - Daft Punk
Best rock performance
Radioactive - Imagine Dragons
Best rock song
Cut Me Some Slack - Paul McCartney, Dave Grohl, Krist Novoselic, Pat Smear
Best rock album
Celebration Day - Led Zeppelin
Best R&B performance
Something - Snarky Puppy with Lalah Hathaway
Best R&B song
Pusher Love Girl - Justin Timberlake
Best R&B album
Girl On Fire - Alicia Keys
Best rap performance
Thrift Shop - Macklemore & Ryan Lewis featuring Wanz
Best rap/sung collaboration
Holy Grail - Jay Z featuring Justin Timberlake
Best rap album
The Heist - Macklemore & Ryan Lewis
Best country album
Same Trailer Different Park - Kacey Musgraves
Best song written for visual media
Skyfall - Adele and Paul Epworth, from Skyfall
Producer of the year, non-classical
Pharrell Williams
Best music video
Suit & Tie - Justin Timberlake featuring Jay-Z
Best music film
Live Kisses - Paul McCartney
For list of more winners, visit the official Grammy Awards website- http://www.grammy.com/nominees
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